In five studies, miR-21 inhibition was obtained in vivo using: (i) a core of phi29 pRNA- three-way junction motif (3WJ) harboring the RNA aptamer for EGFR (3WJ/EGFRapt/anti-miR21) [132], (ii) a core of 3WJ harboring the aptamer binding to CD133 receptor (3WJ/CD133apt/anti-miR21) [113], (iii) polydopamine (PDA)-based NPs [68], (iv) tumor extracellular vesicles complexed with gold-iron oxide NPs (TEV-GIONs) [107] and (v) RNA nanospheres into nanopompons [47]. Here, EGFR is linked to neoplasm.