Thus, Minner et al. described that a detectable HER2 immuno-staining on primary tumor was observed in 17.5% and 22.5% (according to the antibodies used) of cases in a cohort of more than 2000 localized PCa, but the large majority of samples had only 1+ staining, indeed a 2+ or 3+ staining was found in only 1.6% of samples included [8]. Here, ERBB2 is linked to posterior cortical atrophy.