An anti-cancer phenotype of neutrophils (N1) is responsible for inflammation processes induced by the release of reactive oxygen species and cytokines (IL-1β, TNF-α, IL-6, and IL-12), however, along with the tumor progression, tumor-associated neutrophils (TANs) acquire a pro-tumorigenic phenotype (N2) and function as suppressors of the immune response. This evidence concerns the gene TNF and neoplasm.