A recent report from Gong et al. demonstrated that activated EGFR signaling results in a rapid inhibition of TNF mRNA through miR-21 induction, and inhibition of EGFR results in amplified TNF mRNA and reduced miR-21 expression levels in lung cancer They also showed TNF activated NF-kB, which in turn induces the transcription of TNF mRNA in a feedforward control [42]. The gene discussed is EGFR; the disease is lung carcinoma.