CD274 and breast cancer: Pre-clinical data suggest that targeting the proangiogenic cytokines Vascular endothelial growth factor A (VEGF-A) and angiopoietin-2 (Ang-2) by a bispecific blocking antibody in an inducible model of BC leads to an increase in PD-L1 expression on epithelial cells in response to the induction of IFNγ and cytotoxic T lymphocytes.