CD274 and neoplasm: In the various cohorts of the Keynote 086 study (phase II), pembrolizumab monotherapy made it possible to obtain higher response rates in patients with PD-L1 positive tumors, in the first line of treatment (ORR: 23%, with 4% achieving complete response), compared to patients who had already received chemotherapy, and not selected for tumor PD-L1 status (ORR: 4.7%) [20].