PDE4A and cancer: Another hypothesis relies on the fact that PDE4 inhibitors possessing a pyridazinone scaffold could exhibit anti-cancer effects independently of PDE4 activity, as demonstrated by Sun et al. Among hypotheses to investigate further, the pyridazinone-based compound inhibition of c-Met kinase, activation of ATM-Chk2 pathway and ROS accumulation and proteasome function impairment have already been suggested [45,46,47].