PMEL and cutaneous melanoma: ABCB5 is a known chemoresistance marker in cutaneous melanoma [26]; gp100 and MART1 are critical in melanosome biogenesis [27]; MCAM is an adhesion molecule, with some recent evidence suggesting that it plays a role in signalling [28]; MCSP can facilitate spreading of cutaneous melanoma, and lastly, S100β inhibits TP53 activity [29].