Autocrine activation of MET by HGF is reported to be an influencing factor in immediate resistance to RAF inhibitors in BRAF positive melanomas as a bypass mechanism by reactivating the mitogen-triggered protein kinase (MAPK) and phosphatidylinositol-3-OH kinase (PI(3)K)-AKT signaling pathways [35]. The gene discussed is BRAF; the disease is melanoma.