In phase Ia/Ib and randomized phase II clinical trials, tiragolumab (an anti-TIGIT antibody) had a tolerable safety profile with promising efficacy (most notably in patients with non-small-cell lung cancer), and clinical trials designed to assess the safety and efficacy of TIGIT inhibitors in patients with RCC are currently ongoing. The gene discussed is TIGIT; the disease is non-small cell lung carcinoma.