The HBV-related HCC patients were significantly younger (p < 0.001) and had better Child-Pugh score (p = 0.027), FIB-4 index (p < 0.001), M2BPGi levels (p = 0.003), a more progressive cancer stage (p < 0.001), and higher AFP levels (p < 0.001) than the HCV-related HCC patients. The gene discussed is AFP; the disease is cancer.