It has been reported that obesity-associated oncogenic drivers, such as adipose tissue remodeling and pro-inflammatory adipokine secretion [16,17], ectopic lipid accumulation and lipotoxicity [18], and the growth effects of insulin and insulin-like growth factors [19,20], promote hepatocarcinogenesis independently or in synergy with major liver histopathology [5]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.