We complemented the IPD data sets with newly generated data sets from three core-clock KO mutants (HCT116-ARNTLKO, HCT116-PER2KO and HCT116-NR1D1KO) and the corresponding WT cells, as well as previously published data sets from two CRC cell lines as indicated above, to investigate possible clock-related alterations relevant in cancer development and neurodegeneration-related genes with a particular focus on PD. The gene discussed is CLOCK; the disease is colorectal carcinoma.