CLOCK and cancer: Furthermore, and to attain a more mechanistic insight in the possible impact of circadian clock disruption in disease-associated pathways, including pathways related to cancer and PD pathogenesis, we complemented our analysis with newly generated time course RNA sequencing (RNA-seq) data sets for CRC cells including the wild type cells (HCT116WT) and three core-clock knockout (KO) cell lines (ARNTLKO, PER2KO and NR1D1KO).