However, instead of ERBB2 and VEGFA amplifications that are frequently observed in EAC [16], this case had oncogenic [27] amplifications of CCND1, FGF19, PIK3CA, BCL6, TERT, PIK3CB, CDK6, and GAB2, almost all of which (all except CDK6) are much more frequently observed in ESCC than EAC (Figure 7D). Here, PIK3CB is linked to esophageal squamous cell carcinoma.