In accordance with the role of RAP1 in cell metabolism, Ferrara-Romeo et al. (2018) showed that RAP1-deficient mice have increased hepatocellular carcinoma susceptibility, which is more acute in females, and upon treatment with carcinogen (diethylnitrosamine), they developed malignant tumors associated with reduced survival in comparison to wild-type mice [89]. The gene discussed is TERF2IP; the disease is hepatocellular carcinoma.