We found that the expression of RAP1 and POT1 at the protein level was positively correlated with the levels of expression and activity of BCR/ABL1, suggesting that BCR/ABL1 kinase expression and activity may upregulate the levels of RAP1 and POT1 and play a crucial role in the maintenance of telomeres in CML cells [36]. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.