GNA11 and neoplasm: Although GNAQ, GNA11, SF3B1, and tumor mutational burden (TMB) were not associated with survival, high baseline mRNA levels of the type 1 IFN inducible and ISGylation gene UBA7, high expression of the type 2 IFN inducible GTPase binding gene GBP1, and high baseline levels of JAK2/STAT4 were associated with tumor shrinkage and overall survival [33].