PRKAA1 and acute myeloid leukemia: In venetoclax-sensitive AML cell lines (HL-60, OCI-AML2, and MOLM-14), incubation with venetoclax generally decreased the half-life of AMPK α, β, and γ isoforms, with a more marked and constant effect on AMPKα (Figure 2B,C, Table 1 and Supplemental Figure S2A,B).