PRKAA1 and acute myeloid leukemia: While the detection of all three AMPK isoforms was similar across AML cell lines, we readily observed a decreased detection of AMPK α, β, and γ s 4 h of incubation with venetoclax in HL-60 and OCI-AML2 cells, and to a lesser extent in MOLM-14 cells (Supplemental Figure S2A,B).