Using fresh tumor tissue from PMP patients and the mucinous LS174T CRC cells, a cell line that shows several features of goblet cells including high levels of MUC2 secretion, has shown that treatment with YC-1 and BAY 87─2243, two specific HIF-1α inhibitors, can significantly decrease MUC2 expression [84]. Here, MUC2 is linked to colorectal carcinoma.