MSLN and acute myeloid leukemia: It is anticipated that immunotherapeutic targeting of MSLN in pediatric AML will be safe and highly beneficial because (1) MSLN function in normal tissues is dispensable [10], (2) MSLN is expressed only on the luminal surface of non-neoplastic cells in the body, a space that is minimally exposed to antibodies in the bloodstream, and (3) MSLN is not expressed in normal bone marrow tissue in children [7,17].