Similarly, the KRYSTAL-1 phase 1/2 trial evaluating adagrasib in patients with advanced or metastatic solid tumors, including KRAS G12C-mutant NSCLC patients who were previously treated with chemotherapy and an anti-PD-1/L1 antibody, showed that 45% of the patients (23/51) achieved a partial response (PR) and 26 patients had stable disease (SD) [80]. Here, KRAS is linked to non-small cell lung carcinoma.