RASSF2 and neoplasm: Due to the absence of RASSF2 promoter hypermethylation in normal colonic tissue already reported in the literature [26,28], and of the absence of such hypermethylation in five mucosae that we have tested at the beginning of this study (data not shown), we did not analyse RASSF2 promoter hypermethylation outside the tumour for all patients in our cohort.