Cancer cell-derived factors, Wnt7a via TGF-β-dependent signaling in breast cancer [35] and galectin-3 via integrin beta 1/ILK/NF-κB signaling in pancreatic cancer [36], have been reported to be involved in the malignant transformation of fibroblasts and stellate cells. This evidence concerns the gene TGFB1 and familial pancreatic carcinoma.