PGRMC2 and ovarian carcinoma: Since miR-21 levels are increased in cisplatin-resistant ovarian cancer cell lines compared to cisplatin-responsive ovarian cancer cells [93] and cisplatin treatment in vitro reduced PGRMC2 levels [95], it is possible that reduced levels of PGRMC2 combined with miR-21 regulation of signaling cascades, which are activated after chemotherapy, facilitates the metastasis of ovarian cancer.