For example, medroxyprogesterone acetate, norethisterone, and dienogest, but not nomegestrol acetate, induce proliferation in MCF7 and T47D breast cancer cells by a mechanism that depends on phosphorylation of a casein kinase 2 domain within PGRMC1 [15,16,17]. The gene discussed is PGRMC1; the disease is breast carcinoma.