Criteria for patients’ selection actually includes age <60, grade G1–G2 with Ki-67 index <10%, and previous removal of primary tumor, metastatic diffusion <50% of the total liver volume and stable disease to therapies for at least 6 months [16,190], with primary tumor site being drained by the portal veinous system also being proposed by some authors [185,190]. Here, MKI67 is linked to neoplasm.