AKT1 and colorectal carcinoma: Toward this end, the MAPK, ErbB, Rap1, mTOR, Ras signaling pathways as well as the Hippo and PI3K–Akt signaling pathways were regulated by all of these miRs, implicating changes in the methylation of the corresponding miR genes as a crucial event in the mediation of CRC progression and metastasis (Figure 5C).