TET2 and hematopoietic and lymphoid cell neoplasm: TET2, which facilitates oxidation of methylcytosine in the DNA, thus contributing to the production of 5-hydroxymethylcytosine, is frequently deregulated in myeloid malignancies, and TET2 inactivation has been proposed to play an initiating role in age-related hematological cancers [422,431,432,433].