CDKN2A and neoplasm: Importantly, no mutations in the DNA repair genes such as TP53, ATM, and ATR were identified in stable MGUS patients, and biallelic inactivation of TP53, RB1, DIS3, MAX, and CDKN2A were rare events for low-risk SMM, suggesting that these abnormalities are associated with tumor progression [48,51,52,62].