The 1q21 region contains several genes whose deregulation or amplification are thought to impact MM progression, including the top candidate, CKS1B, encoding the cyclin-dependent kinase regulatory subunit 1B [532] as well as several other genes: PSMD4 encoding the proteasome 26S subunit, IL6R encoding the interleukin 6 receptor, MCL1 encoding the BCL2 family anti-apoptotic protein, ANP32E encoding H2A.Z histone chaperone, ADAR1 encoding adenosine deaminase, and ILF2 encoding the interleukin enhancer-binding factor 2 [476,530,531,533]. The gene discussed is BCL2; the disease is Miyoshi myopathy.