Missense mutations clustered in the regions corresponding to the highly conserved globular domain of the linker histones encoded by genes HIST1H1B, HIST1H1C, HIST1H1D, HIST1H1E, HIST1H2BK, and HIST1H4H were found in MM cells [61,82,86,398,415]. Here, H1-4 is linked to Miyoshi myopathy.