The importance of molecularly based subgroups has later been underlined in several analysis (e.g., in a post hoc analysis of a large cohort of children and adults with metastatic disease) and available tissue material 5-year EFS and OS differed between low-risk (WNT, n = 4; both 100%), high-risk (MYCC/MYCN amplification; n = 5, both 20%) and intermediate-risk patients (neither; n = 72, 63% and 73%), respectively [27]. Here, MYC is linked to metastatic neoplasm.