For example, LNC-SOX5, which is associated with carcinogenesis of tongue carcinoma, has also been reported to function on the regulating cytotoxicity of CD8+ T cells in colorectal cancer [54,125], while at present, the function of LNC-SOX5 in regulating the CD8+ T cell cytotoxicity effect in OSCC remains unclear. The gene discussed is CD8A; the disease is tongue cancer.