Growth-arrest-specific transcript 5 (GAS5) is another representative lncRNA that has been widely reported as a tumor suppressor in many cancers; Zeng et al. also confirmed that GAS5 functions as a tumor suppressor in OSCC via the miR-21/PTEN axis to inhibit tumor cell proliferation, migration, invasion, and EMT [46]. The gene discussed is PTEN; the disease is neoplasm.