AKT1 and cancer: Interestingly in this regard, recent reports on the effect of two GSK inhibitors, SB 415286 and RO-81220, also highlighted the role of GSK-3 in regulating mitotic checkpoint levels in multiple cancer cell lines, prolonging mitotic arrest and upstream regulating P13K/Akt signaling arcs and deacetylase sirtuin2 as a GSK-3 downstream target [41,42,43,44,45].