CTNNB1 and colorectal carcinoma: On the other hand, CTNNB1 mutations are less often (5% non-hypermutated (nHM) CRC; 7% hypermutated (HM) CRC) involved in sporadic human colorectal carcinogenesis than APC (Adenomatous polyposis coli) mutations (81% nHM; 53% HM CRC) [20].