Interestingly, in earlier studies Orai3 was reported to encode diverse form of Ca2+ influx channels in different cancer types, i.e., homomeric SOCE channel in estrogen receptor expressing breast cancer cells [23,24,25]; heteromeric ARC channel in LNCaP prostate cancer cells [32] and very recently heteromeric SOCE channel in MiaPaCa2 cells [33]. This evidence concerns the gene ESR1 and cancer.