KLK3 and metastatic neoplasm: A review of 42 studies concluded that the Decipher genomic classifier score higher than 0.6 after localized treatment is a strong predictive factor for biochemical failure (defined as two consecutive PSA values of more than 0.2 ng/mL in patients who underwent radical prostatectomy [109] or any increase in PSA greater than or equal to 2 ng/mL higher than the PSA nadir in patients with radiotherapy [110] and metastatic disease [111].