In our previous works, 1C1m-Fc, a novel anti-TEM-1 ScFv-Fc construct, which binds both murine and human TEM-1, has been conjugated to a BFCA, p-SCN-Bn-DOTA, radiolabeled with 177Lu and evaluated in a TEM-1-positive tumor model in mice. Here, CD248 is linked to neoplasm.