Network analysis using IPA of the differentially expressed proteins in the diffuse subtype showed increased expression of proteins like HSPB1, KCTD, TPM3, PDLIM7, LUZP1, ACTN1, and CFL2; and decreased expression of proteins involved in the mitochondrial respiratory chain like NFU1, ACO2, PDHA1, and tumor suppressors like DECR1, CNDP2, and SPINT1 in the topmost network. Here, ACO2 is linked to neoplasm.