Downregulation of proteins involved in the mitochondrial respiratory chain like NFU1 [54,55], ACO2 [56], PDHA1 [57], and proteins like DECR1 [58], CNDP2 [59], and SPINT1 [60,61], which have a tumor suppressive role in different cancers were noted. This evidence concerns the gene PDHA1 and neoplasm.