The Q-value, coverage and GO annotation are shown in Figure 4B. Furthermore, collagen type I and 3 alpha chain (COL1A2 and COL3A1), decorin (DCN), fibronectin (FN1), regulator of G protein signaling (RGS2), and secreted phosphoprotein (SPP1) were significantly downregulated in bladder cancer specimens, compared to noncancerous tissues (Supplementary Table S2). This evidence concerns the gene RGS2 and urinary bladder carcinoma.