Besides, our analysis highlighted several attributed genes and their associated signaling network involved in bladder cancer prognosis, including the family of ubiquitin-conjugating enzymes (UBE2C, UBE2D1, and UBE2E1), regulatory protein involved in mitosis (CCNB1), cell division cycle protein ubiquitin ligase (CDC16, CDC23, and CDC26) that are components of the multiprotein APC complex. Here, UBE2E1 is linked to urinary bladder carcinoma.