SPP1 and urinary bladder cancer: The Q-value, coverage and GO annotation are shown in Figure 4B. Furthermore, collagen type I and 3 alpha chain (COL1A2 and COL3A1), decorin (DCN), fibronectin (FN1), regulator of G protein signaling (RGS2), and secreted phosphoprotein (SPP1) were significantly downregulated in bladder cancer specimens, compared to noncancerous tissues (Supplementary Table S2).