In the GSE37317 dataset, 7975 DEGs were noted and the pathways significantly overrepresented were molecular mechanism of cancer, hepatic fibrosis, glucocorticoid receptor signaling, and cardiac hypertrophy signaling, Huntington disease signaling, senescence pathway, hereditary breast cancer signaling, colorectal cancer metastasis, NRF2-mediated oxidative stress response, estrogen receptor signaling, axonal guidance signaling, and aryl hydrocarbon receptor signaling. The gene discussed is ESR1; the disease is Huntington disease.