In GSE154261 dataset, a total of 6078 DEGs were identified with significant enrichment in canonical pathways that include molecular mechanisms of cancer, mitochondrial dysfunction, protein ubiquitination pathway, oxidative phosphorylation, sirtuin signaling pathway, EIF2 signaling, senescence pathway, mTOR signaling, HER-2 signaling, estrogen receptor signaling, IGF-1 signaling, and hepatic fibrosis pathways. This evidence concerns the gene ESR1 and Hepatic fibrosis.