CDKN2A showed high level of expression (301.31, 2078.34, and 555.12 fold) in transitional papilloma RT4 cells, HT1197 cells, and 253JB-V cell line whereas J82 cells showed down-expression 0.5 fold at p-value 0.000. Here, CDKN2A is linked to transitional cell papilloma.