CD274 and neoplasm: In these trials, PD-L1 status has been reported using combined positive score (CPS) or tumor positive score (TPS): while CPS is defined as the number of PD-L1 staining cells (tumor cells, lymphocytes, macrophages, etc.,) divided by the total number of viable tumor cells, TPS only considers PD-L1 staining tumor cells in the nominator.