In addition, similar to the tiered recommendation of nivolumab from CHECKMATE-649, the NCCN guidelines have listed first-line pembrolizumab with chemotherapy (either cisplatin category 1 or oxaliplatin category 2A) for tumors with PD-L1 CPS ≥ 10 for both SCC and AC esophageal/GEJ cancers, while tumors with PD-L1 CPS 1-9 have category 2B recommendation, and PD-L1 CPS 0 is currently not recommended [59]. The gene discussed is CD274; the disease is esophagitis.