Additionally, CXCR4 has recently emerged as an interesting molecular target in marginal zone lymphoma [14,15], gastric mucosa-associated lymphoid tissue (MALT) lymphoma [16], mantle cell lymphoma [17], myeloproliferative neoplasms [18] as well as primary lymphoma of the central nervous system [19]. The gene discussed is CXCR4; the disease is primary central nervous system lymphoma.