TYR and cutaneous mastocytosis: Keilholz et al. analyzed circulating mRNA levels of three markers, namely TYR, MLANA (MelanA, previously known as MART-1), and PMEL (premelanosome protein, previously known as gp100), in the tissue and blood of CM patients, in the tissue from liver metastasis and the blood of UM patients, and in healthy individuals [100].