The mechanisms underlying the destabilization of the epithelial cell–cell junctions, loss of apical-basal polarity, reorganization of the cytoskeletal architecture and an increase capability to invade, as well as to degrade ECM, are correlated with the downregulation of E-cadherin and up-regulation of mesenchymal markers, such as vimentin, N-cadherin, and fibronectin in BC cells [66,67,68]. The gene discussed is CDH1; the disease is breast cancer.