ERBB2 and breast cancer: TMEM score was positively associated with distant recurrence-free interval (p = 0.001) and recurrence-free interval (p = 0.00006) in ER+/HER2- BC patients within the first 5 years of follow-up after surgery, suggesting a possible role in providing prognostic information for early recurrence complementary to clinicopathological features and recurrence score [17,106].