CXCL12 and neoplasm: These inflammatory CAFs release factors, such as TGFβ-1, C-X-C motif chemokine ligand 12 (CXCL12), PDGF and IL-6, that enhanced tumor cell dispersion, scattering, and migration, by stimulating the chemokine receptors CCR2, CCR5, and CXCR1/2 and Ras-activating receptors, expressed by BC cells [125].