ERBB2 and carcinoma: CAFs subsets were recently identified by multicolor flow cytometry: CAFs1 are involved in ECM organization and maintain an immunosuppressive microenvironment, especially in HER-2 positive carcinomas and TNBCs [128]; CAFs2 are equally distributed in intra-tumoral and extra-tumoral stroma and are enriched in Luminal A carcinomas; CAFs4 are more present in HER-2 positive carcinomas and TNBCs and play a crucial role in muscle contraction [128].