Of note, it has been recently demonstrated that tumor cells may reach the bloodstream through specific micro-anatomical structures called tumor microenvironment of metastasis (TMEM), a three-cell complex composed of a perivascular macrophage, a tumor cell expressing high levels of actin-regulatory protein mammalian enabled (Mena), and an endothelial cell [17,18]. The gene discussed is EGFR; the disease is neoplasm.