As opposed to sporadic colorectal cancer (CRC), which is typically initiated by somatic alterations in WNT pathway tumor suppressor APC, followed by alterations in KRAS and SMAD4, CAC demonstrates a distinct pattern of genomic alterations notable for early TP53 mutations [45,46,47], and a significantly lower frequency of APC mutations [48,49]. Here, KRAS is linked to colorectal carcinoma.