If not directly altered, other factors that regulate TP53 are also dysregulated, such as MDM2 and WWOX, the latter of which is a tumor suppressor found in a common chromosomal fragile site, and a regulator of the DNA damage response, whose protein expression is absent in up to 65% of gastric adenocarcinomas [12,13,14,15]. This evidence concerns the gene TP53 and neoplasm.