IL6 and cholangiocarcinoma: Exosomes isolated from cholangiocarcinoma cultures induced IL-6 expression in the vCAFs, and the authors showed that exosomal miR-9-5p is responsible for this enriched IL-6 expression and release by the CAF compartment and in response to the enhanced IL-6, EZH2, and malignancy were induced in the tumour [72].