The loss of 3p results in the simultaneous loss of three other tumor suppressor genes that are frequently mutated in CCRCC: Polybromo 1 (PBRM1) (~50%), SET domain containing 2 (SETD2) (~20%), and BRCA1-associated protein 1 (BAP1) (~15%) [26,32,36]. This evidence concerns the gene SETD2 and nonpapillary renal cell carcinoma.