PDIA3 interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins [35], and the low expression of PDIA3 has been associated with poor overall survival for non-small lung cancer and gastric cancer, due to the formation of a complex with MHC class I [35,36,37], corroborating with our results. This evidence concerns the gene CANX and gastric cancer.