Moreover, these mutations lead to a 100% cytosolic NPM1 relocation (which was also observed here in some DLBCL cases, whereas no such mutations have ever been described in B-NHL) but do not result in the specific mixed pan-cellular NPM1 staining pattern associated with poor prognosis, which has never been reported to date to our knowledge. The gene discussed is NPM1; the disease is diffuse large B-cell lymphoma.