Furthermore, in chronic eosinophilic leukemia cells, Jin et al. found that ponatinib can induce a release of apoptosis-inducing factor and cytochrome C from the mitochondria into the cytosol, which in turn triggers the mitochondrial apoptosis pathway [55]. The gene discussed is CYCS; the disease is Chronic Eosinophilic Leukemia, Not Otherwise Specified.