MYCN-amplification is genetically defined as anything from 9 copies up to 500 copies, which are typically localized in double minutes or homogenously stained regions [34] High-risk MYCN-amplified neuroblastomas commonly exhibit loss of heterozygosity at chromosome 1p as well as gain of 17q, with 70% of MYCN amplified neuroblastoma associated with 1p36 deletions [24,35]. This evidence concerns the gene MYCN and neuroblastoma.