This mechanistic explanation of a role for DLG2 as a tumor suppressor was accompanied by a comprehensive genetic analysis of 120 11q-deleted neuroblastoma cases that was able to identify DLG2 as the most proximal gene in the shortest region of genetic overlap in patient material, with DLG2 disrupted in all 11q deleted cases examined [21]. Here, DLG2 is linked to neuroblastoma.