In a case–control study [44], a combined appearance of two SNPs within TAS2R3 and TAS2R4 was associated with a decreased risk of papillary thyroid carcinoma (OR—0.59; 95% CI—(0.36, 0.97); p = 0.036) and linked with lower total triiodothyronine concentration in the serum, indicating that genetic variations of TAS2Rs can impact tissue-specific functions, which might play a role in carcinogenesis. The gene discussed is TAS2R3; the disease is differentiated thyroid carcinoma.