Based on the results of multivariate Cox regression analysis, a prediction model and nomogram were developed using the independently associated factors (categorized age, presence of cirrhosis, platelet count, and categorized liver stiffness values [<7.5, 7.5–9.6, 9.6–11.0, 11.0–14.0, and ≥14.0 kPa]), together with categorized serum albumin levels (≥3.4, 2.8–3.4, and <2.8 g/dL), total bilirubin levels (<2.0 and ≥2.0 mg/dL), and HBeAg positivity, which were reported to be closely associated with the HCC risk among subjects with chronic HBV infection [12,13,15]. The gene discussed is ALB; the disease is hepatocellular carcinoma.