EGFR and head and neck squamous cell carcinoma: Interestingly, cetuximab is an anti-EGFR, human-murine chimeric IgG1 isotype mAb and has been approved for the treatment of HNSCC in combination with chemotherapy in the R/M setting and with radiation therapy in the curative setting, although was shown to be inferior to standard cisplatin-radiation therapy in low-risk HPV-positve OPSCC [52].