Finally, DCs have also been reported to induce a premetastatic niche during lymph node cancer dissemination, via cyclooxygenase-2 (COX-2)/EP3-dependent induction of stromal cell-derived factor 1 (SDF-1) in a murine model of Lewis lung carcinoma [47]. The gene discussed is CXCL12; the disease is Carcinoma, Lewis Lung.