Experiments performed in gastric cancer cell lines and a glioblastoma cell line indicated that epigenetic silencing of the miR-200b/200a/429 promoter is mediated by CpG methylation catalyzed by DNMT1 (DNA methyltransferase 1) and EZH2-directed histone 3 trimethylation (H3K27me3), with recruitment of DNMT1 depending on EZH2 [70]. Here, EZH2 is linked to glioblastoma.