GRHL2 and ovarian carcinoma: In ovarian cancer cells, the transcription factor GRHL2 (grainyhead-like 2) was shown to favor the epithelial phenotype by increasing miR-200b/200a/429 expression through direct transcriptional activation and by reducing the levels of the repressive histone H3K27me3 mark in the cluster’s promoter and CpG island [88].