SESN3 and hepatocellular carcinoma: Sestrin 3 (SESN3) is a stress response gene that protects the liver from carcinogen-induced hepatocellular carcinoma, and knockdown of SESN3 promotes carcinogen-induced hepatocellular carcinoma and metastasis by regulating hedgehog signaling, enhancing the production of extracellular matrix, and inducing cancer stem cell markers [66].