Using the normalized read counts from RNA-Seq, the expression of five genes (CXCR4, SESN3, PD-L1, PTN, and EPHA5) was upregulated while the expression of two genes (ADORA1 and DTX4) was downregulated in PC3 (Figure 5B) and MDA-PCa-2 cells (Figure 5C). This evidence concerns the gene SESN3 and posterior cortical atrophy.